Preorganized, Macromolecular, Gene-Delivery Systems
نویسندگان
چکیده
منابع مشابه
Gene Delivery Systems
Gene therapy has undergone a remarkable development in the last 20 years. Particularly important advances have been made in the improvement of gene transfer and expression technology, with current efforts focusing on the design of safer and long-term gene expression vectors as well as systems possessing cell-type specificity for transgene delivery and regulat‐ ability of its expression by small...
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The use of macromolecules, particularly monoclonal antibodies, as therapeutic agents has come to the forefront in recent years. The biodistribution and delivery issues for protein drugs are shared to a substantial degree with other emerging therapeutic approaches including pharmacologically active nucleic acids and nanoparticles. A generalized approach to these issues involves consideration of ...
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1Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandarsindri, N.H. 8, Tehsil Kishangarh, District Ajmer, Rajasthan 305817, India 2Genomics and Nanotoxicology, Laboratory Mechanistic Studies Division, Health Canada, Ottawa, ON, Canada K1A 0K9 3Department of Electro and Biophysics, Plasma Bioscience Research Centre, Kwangwoon University, Wolgye-Dong, Nowon-...
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Geminal frustrated Lewis pairs (FLPs) are expected to exhibit increased reactivity when the donor and acceptor sites are perfectly aligned. This is shown for reactions of the nonfluorinated FLP tBu(2)PCH(2)BPh(2) with H(2), CO(2), and isocyanates and supported computationally.
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Recent advances in molecular biology combined with the culmination of the Human Ge‐ nome Project [1] have provided a genetic understanding of cellular processes and disease pathogenesis; numerous genes involved in disease and cellular processes have been identi‐ fied as targets for therapeutic approaches. In addition, the development of high-throughput screening techniques (e.g., cDNA microarra...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2010
ISSN: 0947-6539
DOI: 10.1002/chem.201000076